Genetics of systemic lupus erythematosus: immune responses and end organ resistance to damage

Genetics of systemic lupus erythematosus

Neurobrucellosis in systemic lupus erythematosus

Background: Brucellosis is a zoonotic infection which is endemic in many countries. It is a multisystem disease which may present with a broad spectrum of clinical manifestations and complications. Neurobrucellosis is an uncommon complication of brucellosis. Case presentation: A 25-year-old woman with a history of lupus for 5 months referred to the emergency ward of Shahid Beheshti Hosp...

Genetics and Epigenetic in Systemic Lupus Erythematosus

Systemic lupus erythematosus (SLE) (OMIM #152700) is the prototype of a multiorgan autoimmune disease and still considered as a disease with an ambiguous etiology. The disease predominantly affects women during the reproductive years at a ratio of eight women per one man (Lopez, 2003). Its pathogenesis is multifactorial lying on genetic and environmental factors in which it occurs in geneticall...

Large Ovarian Hemorrhagic Cyst and Immune Thrombocytopenia as Early Manifestations of Systemic Lupus Erythematosus (SLE)

Hematologic abnormali"es are generally present among systemic lupus erythematosus pa"ents. Idiopathic thrombocytopenic purpura can be the first manifesta"on of SLE, followed by other symptoms and signs of disease appearing several years later. Although bleeding due to immune thrombocytopenic purpura is usually mild and occurs in mucocutaneous surfaces, but it may be severe and represent in u...

Systemic lupus erythematosus genetics: what’s new?

Benjamin Rhodes & Timothy J Vyse† †Author for correspondence Imperial College London, Section of Molecular Genetics and Rheumatology, Faculty of Medicine, Du Cane Road, London, W12 0NN, UK Tel.: +44 208 383 2339; Fax: +44 208 383 2379; [email protected] ‘Identifying SLE susceptibility genes is important because they will highlight pathways fundamental to the development of SLE, and may, in ...